|
KMID : 0378019780210030056
|
|
New Medical Journal
1978 Volume.21 No. 3 p.56 ~ p.60
|
|
|
Hypotensive Action of Eucommiae Cortex in Rat
|
|
|
|
|
Abstract
|
|
|
|
Eucommia ulmoides Oliver which belongs to Eucommiaceae family, has been used in the chines medicine as well as in the folk remidies. It is advocated that this herb exerts good therapeutic effects on a large variety of disorders, e.g. neuralgia, hypertension etc. by analgesic, tranquilizing and hypotensive effects. However the basic pharmacology and the mechanism of hypotensive action are not clear. This experiment was carried out in order to evaluate the hypotensive action of Eucommiae cortex methanol extract (EM) and to clarify the mechanism of action in the rats. The results of the experiments were as follows: 1) Blood pressure manifested gradual responses by the fall of -20.1, -29. 8 and -54.2 mmHg in proportion to the administration of 30, 60 and 80 mg/kg of EM respectively. 2) Prior administration of atropine attenuated the decrease in blood pressure induced by EM (60 mg/kg) slightly, but not significantly. 3) Prior administration of diphenhydramine attenuated significantly the decrease in blood pressure induced by EM (60 mg/kg) . 4) Prior administration of dichloroisoproterenol did not blocked the decrease in blood pressure induced by EM (60 mg/kg) . 5) Administration of epinephrine (20 mg/kg) to the rat pretreated with EM (60 mg/kg) did not show difference in the increase of the blood pressure compared with that of normal rat.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|